Efficacy and Safety of Cannabidiol in Epilepsy Systematic Review

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• 1 mg
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Approximately one-third of patients with epilepsy presents seizures despite adequate treatment Hence there is the need to search for new therapeutic options Cannabidiol CBD is a major chemical component of the resin of Cannabis sativa plant most commonly known as marijuana The antiseizure properties of CBD do not relate to the direct action on cannabinoid receptors but are mediated by a multitude of mechanisms that include the agonist and antagonist effects on ionic channels neurotransmitter transporters and multiple 7-transmembrane receptors In contrast to tetrahydrocannabinol CBD lacks psychoactive properties does not produce euphoric or intrusive side effects and is largely devoid of abuse liability The aim of the study was to estimate the efficacy and safety of CBD as adjunctive treatment in patients with epilepsy using meta-analytical techniques