The effects of acute chronic and withdrawal from chronic nicotine on novel and spatial object recognition in male C57BL 6J mice
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$39.95
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1 mg
Description
Spatial and novel object recognition learning is different from learning that uses aversive or appetitive stimuli to shape acquisition because no overt contingencies are needed. While this type of learning occurs on a daily basis, little is known about how nicotine administration affects it. To determine the effects of acute, chronic, and withdrawal from chronic nicotine on two related but distinct incidental learning tasks, novel and spatial object recognition. In C57BL/6J mice, the effects of acute (0.045–0.18 mg/kg), chronic (6.3 mg/kg/day), and withdrawal from chronic nicotine on novel and spatial object recognition were examined. With a 48-h delay between training and testing, acute nicotine enhanced spatial (difference score, saline = 3.34 s, nicotine = 7.71 s, p = 0.001) but not novel object recognition (difference score, saline = 2.88 s, nicotine = 3.49 s, p = 0.68). Chronic nicotine had no effect on spatial (difference score, saline = 4.20 s, nicotine = 3.82 s, p = 0.78) or novel (difference score, saline = 3.00 s, nicotine = 0.17 s, p = 0.004) object recognition. However, withdrawal from chronic nicotine enhanced spatial object recognition (difference score, saline = 3.00 s, nicotine = 0.17 s, p = 0.004) but had no effect on novel object recognition.
