Mecamylamine elicits withdrawal like signs in rats following a single dose of nicotine

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This scientific article investigates whether the nicotinic acetylcholine receptor antagonist mecamylamine induces withdrawal-like behaviors in rats after just a single dose of nicotine. Using both physiological and behavioral measurements such as increased intracranial self-stimulation thresholds and observable somatic changes, researchers demonstrate clear parallels to classic nicotine withdrawal syndromes seen under prolonged use conditions.