Evidence cannabidiol pharmacokinetics tetrahydrocannabinol man

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This downloadable article presents a controlled investigation into the interaction between intravenously administered delta 9 tetrahydrocannabinol and high dose oral cannabidiol in human subjects. It carefully characterizes plasma pharmacokinetics, metabolite formation, and clearance parameters under crossover conditions to clarify whether cannabidiol meaningfully alters tetrahydrocannabinol disposition.