Modification of Delta 9 THC Actions by Cannabinol and Cannabidiol in the Rat

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This scientific article investigates how cannabinol (CBN) and cannabidiol (CBD) modify the physiological effects of δ⁹-tetrahydrocannabinol (Δ) in rats. While both CBN and CBD showed limited individual psychoactive properties at certain dosages, they significantly influenced the metabolic behavior and duration of THC’s impact—particularly enhancing sleep times induced by barbiturates when combined with CBD.