Comparative Analgesic Activity Of Various Naturally Occurring Cannabinoids In Mice And Rats

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This scientific study compares the analgesic effects of several natural cannabinoids—including Δ⁹-tetrahydrocannabinol (THC), cannabinol (CBN), cannabidiol (CBD), and crude marijuana extract—against traditional drugs like morphine and aspirin in rodent models. Using standardized pain assays such as the acetic acid writhing test, hot plate test, and Randall Selitto paw pressure test, researchers evaluated potency across species and modalities.