Anxiogenic like effects of chronic cannabidiol administration in rats

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The present study investigated the effects of chronic administration of CBD on rat behaviour and on the expression of brain proteins. Male Lister-hooded rats received daily injections of CBD for 14 days and were subjected to two behavioural tests: locomotor activity and conditioned emotional response (CER). CBD significantly increased the time spent freezing in the CER test with no effect on locomotor activity. CBD decreased the expression of several key proteins in the hippocampus and frontal cortex, including BDNF and TrkB expression.