Insulin Therapy in Adults with Type 1 Diabetes Mellitus

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Here, we review insulin management options and strategies in nonpregnant adult patients with type 1 diabetes mellitus (T1DM). Most patients with T1DM should be treated with multiple daily injections (MDI) of basal and prandial insulin or continuous subcutaneous insulin infusion (CSII). The starting total daily insulin dose is typically weight based, ranging from 0.4 to 1.0 units per kilogram body weight. Insulin replacement is necessary for all people with T1DM and involves multiple daily injections of basal and prandial insulin or continuous subcutaneous insulin infusion. This article is based on previously conducted studies and does not contain any studies with human participants or animals performed by any of the authors.