Pharmacological interaction between cannabidiol and delta 9 tetrahydrocannabinol

• $39.95
• 1 mg
• Link.springer.com

The pharmacological interaction between cannabidiol (CBD) and (−)δ9-trans-tetrahydrocannabinol (δ9-THC) has been studied in rabbits, mice and rats by administering mixtures containing varying amounts of both substances. CBD blocked the following effects of δ9-THC: catatonia in mice, corneal areflexia in rabbits, the increased defecation and decreased ambulation after chronic treatment and exposures of rats in an open field arena, and the aggressiveness of rats previously stressed by REM sleep deprivation. On the other hand, CBD potentiated the δ9-THC-induced analgesia in mice and the δ9-THC-impairing effect on climbing rope performance of rats. These interactions are tentatively explained by postulating that CBD directly antagonizes the excitatory effects and or indirectly potentiates the depressant effects of δ9-THC.